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Physiology

Membrane potential

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Apply Nerst and Goldman-Hodgkin-Katz (GHK) equations to calculate membrane potential on a section of membrane as it goes through an action potential. Mathematically demonstrate how changing permeability through the activation of transport membrane protiens chages membrane potential.

Learning outcomes

  • Identify the direction concentration gradient and electrochemical gradient across a membrane.
  • Calculate the membrane potential of a single ion using the Nernst equation.
  • Calculate the membrane potential of multiple ions using Goldman-Hodgkin-Katz (GHK) equation.
  • Identify trans-membrane proteins that alter the permeability of ions across a membrane, and the resulting membrane potential changes throughout an action potential.
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Skills

Interpreting and Analysing Data

  • How to interpret membrane data and diagrams to identify concentrations and permeability
  • How to determine the electrochemical and concentration gradients

Concepts, Principles and Theories

  • What a membrane potential is
  • How membrane potential is affected by changes in confirmation to membrane transport proteins
  • How the potential of a membrane changes throughout a action potential

Manipulating and Presenting Data

  • How to calculate the membrane potential using the Nerst and GHK equations

Learn more about our approach to skills
Dr. Alexandra Moores
School of Biosciences, University of Kent

The Smart Worksheet was extremely useful to see the overall understanding and application of theories that we expected students to be able to use. The feedback is clear and accessible, enabling students to gain a deeper understanding of the topic they are studying and aiding in their success.

Details

Degrees

Biological science
Biomedical science
Foundation science

Modules

Tissue and cell biology

Topic

Physiology

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