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Clinical biochemistry

Drug metabolism and pharmacokinetics

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Explore the conceptual and mathematical frameworks of pharmacokinetics in the context of drug metabolism. Evaluate how drugs are administered, metabolised, and eliminated based on their relative kinetics and engage with the principles of Michaelis-Menten kinetics while use them to predict kinetic relationships.

Learning outcomes

  • Evaluate how drugs are used and administered, then determine how they are metabolised.
  • Demonstrate an understanding of the mathematical concepts of pharmacokinetics and apply them to calculate the key variables.
  • Examine the principles of of Michaelis-Menten kinetics and use them to calculate the reaction rate and predict kinetic relationships.
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Skills

Manipulating and Presenting Data

  • Calculate the area under the curve (AUC), bioavailability, absolute and normalised apparent volume of distribution, elimination rate constant, half-life and initial plasma concentration
  • Identify the y-intercept and calculate clearance
  • Use the Michaelis-Menten equation to determine the reaction rate (V)

Interpreting and Analysing Data

  • Interpret data in order to identify elimination kinetics and regression
  • Interrelate the terms in the equation for exponential decay to the equation of a line
  • Use substrate concentrations to identify elimination kinetics using the Michaelis-Menten framework

Concepts, Principles and Theories

  • Explore the principles of drug uses, administration, metabolism and bioavailability
  • Recall the apparent volume of distribution and the format of a linear equation

Learn more about our approach to skills
Sheri Scott, Principal Lecturer and Biomedical Science Subject Lead, Nottingham Trent University and IBMS Council Member

“One of the biggest challenges for students is moving beyond viewing laboratory results as individual numbers and instead recognising them as part of a broader picture of patient health. They need to learn how to interpret patterns across multiple biomarkers while considering the reliability of the data, thus developing the ability to link findings to the underlying disease processes and the patient’s clinical picture.”

Details

Subject areas

Biomedical science

Discipline

Clinical biomedical science

Topic

Clinical biochemistry

Purchase option

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