Genetics

Phylogenetics

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Explore the principles behind phylogenetics including the anatomy of a phylogenetic tree and what each component means. Apply these skills to determine evolutionary ancestry based on observation of novel phylogenetic trees. Further delve into the concepts of branch lengths and what they measure, and how topology impacts the interpretation of phylogenetic trees. Then, identify different methods of rooting a phylogenetic tree and how that impacts the relative topology.

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Learning outcomes

• Recall the principles of phylogenetics and how phylogenetic trees can be used to trace evolutionary relationships and ancestry.
Identify and label the key components of a phylogenetic tree.
Use a phylogenetic tree to interpret common ancestry.
Modify and examine branch lengths and topology of a phylogenetic tree and interpret evolutionary similarity and divergence.
Calculate branch data and identify substitutions whilst examining phylogenetic reconstructions to predict method bias, models and rooting types.

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Skills

Manipulating and Presenting Data

How to calculate nucleotide substitutions per site without the aid of a complex evolutionary model

Interpreting and Analysing Data

How to interpret multiple family and phylogenetic trees, using them to identify common ancestry
How to interpret a phylogenetic tree based on topology and infer evolutionary divergence based on branch length and associated metadata
Determining the problems associated with simple calculation methods and how mutation mechanism can impact rates of evolution
Exploring different ways trees can be visualised and how rooting changes the meaning and interpretation of a tree

Concepts, Principles and Theories

Defining the principles of phylogenetics by distinguishing the different components of a phylogenetic tree
Defining the typical units represented in branch lengths
Defining why phylogenetic trees are rooted in order to give context

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Dr. Alexandra Moores

University of Kent

"The Smart Worksheets are extremely useful to see the overall understanding and application of theories that we expected students to be able to use. Feedback is clear and accessible, enabling students to gain a deeper understanding of the topic they are studying and aiding in their success.”

Details

Degrees

Biological science

Biomedical science

Foundation science

Modules

Molecular biology

Topic

Genetics

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