Clinical biochemistry

Therapeutic drug monitoring and steady state

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Revisit the principles of drug elimination, metabolism and pharmacokinetics, expanding and applying them in the context of therapeutic drug monitoring. Explore the concept of steady state and apply critical calculations to a clinical scenario to ensure accurate drug concentration maintenance within a therapeutic window.

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Learning outcomes

Demonstrate an understanding of the mathematical concepts of pharmacokinetics and apply them to calculate the key variables.
Assess the mathematical concepts of steady state and use them to calculate the key variables.
Apply pharmacokinetic concepts to a novel clinical scenario, then analyse and interpret complex data to determine the therapeutic window.

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Skills

Manipulating and Presenting Data

Calculate the individual and total area under the curve (AUC) for some pharmacokinetic elimination data
Extrapolate the AUC to infinity and use this to calculate drug bioavailability
Calculate the point at which steady state is achieved for a specific drug regime
Calculate all the pharmacokinetic parameters for a patient in a clinical scenario

Interpreting and Analysing Data

Explore how apparent volume of distribution is impacted by weight

Concepts, Principles and Theories

Explore how the equation of a line relates to pharmacokinetic measurements
Define how drugs are modified and characterise the principles of steady state

Learn more about our approach to skills

Dr Linda Walsh, Senior Lecturer, Glasgow Caledonian University and IBMS Council Member

“Clinical biochemistry is a complex subject area which requires applying fundamental knowledge in a variety of clinical areas. Students often struggle to connect the pathways required to integrate their knowledge, therefore using patient case studies allows the knowledge they have to be applied in real-life scenarios. This makes the reliance on memorising and recall less necessary.”

Details

Degrees

Biomedical science

Discipline

Clinical biomedical science

Topic

Clinical biochemistry

Purchase option

The Smart Worksheet Library

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