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Organ bath

Organ Bath - Aorta

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Learn about how an organ bath works and how it can be used to determine the effect of drugs on an isolated piece of aorta. Practise using the equipment to wash a piece of tissue and determine the effect of 4 drugs, including acetylcholine and histamine on the aorta. Analyse a force-time trace to identify the effect of each drug on the tissue.

Learning outcomes

  • Consider the role of different parts of the organ bath equipment
  • Determine the effect of four different drugs on aorta
  • Relate the shape of the force-time trace to the underlying pharmacology
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Using Instruments and Equipment

  • What are the different parts of the organ bath equipment
  • How to run a single wash cycle 

Obtaining and Recording Data

  • Why the tissue must be washed in between drug applications
  • How to annotate the force-time trace generated by the chart recorder

Interpreting and Analysing Data

  • How to describe changes in force recorded on a force-time trace 
  • How to determine the effect of different drugs on the aorta by analysing a force-time trace

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Dr. Sharon Williams
Coventry University

“Before attending the labs, students are encouraged to use the bioscience or chemistry materials to understand the practicals better. This makes the students more confident when attending the labs.”



Pharmacological science
Biomedical science




Organ bath

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